Association between COMT gene rs165599 SNP and schizophrenia: A meta-analysis of case-control studies

The differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia.

Association study of single nucleotide polymorphism rs165599 of COMT gene, with schizophrenia and bipolar mood disorder in the south-west of Iran

Linkage studies and epidemiological findings indicate that some possible genes in schizophrenia (SCZ) and bipolar mood disorder (BPD) are common. Numerous evidences for linkage of two diseases on chromosome 22 have been found. These findings suggest that one or more genes in the 22q11.21 region may be involved in the development of both disorders. In the present case-control study, association ...

Association of PDE4B Polymorphisms with Susceptibility to Schizophrenia: A Meta-Analysis of Case-Control Studies

BACKGROUND The PDE4B single nucleotide polymorphisms (SNPs) have been reported to be associated with schizophrenia risk. However, current findings are ambiguous or even conflicting. To better facilitate the understanding the genetic role played by PDE4B in susceptibility to schizophrenia, we collected currently available data and conducted this meta-analysis. METHODS A comprehensive electroni...

The Association between GNB3 Gene Polymorphism and Obesity: A Systematic Review and Meta-Analysis

The association between Guanine Nucleotide Binding protein β protein polypeptide 3(GNB3) C825T polymorphism and obesity has recently been reported. However, the findings remain inconclusive. The aim of this systematic review and meta-analysis was to detect the relationship between GNB3 C825T polymorphism and obesity. Materials and Methods: Six electronic databases including Embase, Medlin...

A highly significant association between a COMT haplotype and schizophrenia.

Several lines of evidence have placed the catechol-O-methyltransferase (COMT) gene in the limelight as a candidate gene for schizophrenia. One of these is its biochemical function in metabolism of catecholamine neurotransmitters; another is the microdeletion, on chromosome 22q11, that includes the COMT gene and causes velocardiofacial syndrome, a syndrome associated with a high rate of psychosi...